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| 產(chǎn)地 | 進口、國產(chǎn) |
| 品牌 | 上海莼試 |
| 保存條件 | Store at -20 °C |
| 貨號 | CS11996 |
| 應(yīng)用范圍 | WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
| CAS編號 | |
| 抗體名 | Anti-UBE2V1/UEV1A |
| 克隆性 | |
| 靶點 | 詳見說明書 |
| 適應(yīng)物種 | 詳見說明書 |
| 形態(tài) | 詳見說明書 |
| 宿主 | 詳見說明書 |
| 亞型 | IgG |
| 標識物 | 詳見說明書 |
| 濃度 | 1mg/1ml% |
| 免疫原 | KLH conjugated synthetic peptide derived from human UBE2V1 |
泛素結(jié)合酶E2變異體1抗體說明書 英文名稱 Anti-UBE2V1/UEV1A
中文名稱 泛素結(jié)合酶E2變異體1抗體說明書
別 名 CIR1; CROC-1; CROC1; CROC1A; TRAF6-regulated IKK activator 1 beta Uev1A; UB2V1_HUMAN; UBE2V 1; UBE2V; UBE2V1; Ubiquitin conjugating enzyme E2 variant 1; Ubiquitin-conjugating enzyme E2 variant 1; UEV-1; UEV1.
產(chǎn)品屬性：
濃 度 1mg/1ml
規(guī) 格 0.2ml/200μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Pig, Horse, Sheep
產(chǎn)品類型 一抗
研究領(lǐng)域 細胞生物 染色質(zhì)和核信號 信號轉(zhuǎn)導(dǎo) 細胞周期蛋白 細胞分化 表觀遺傳學(xué)
蛋白分子量 predicted molecular weight: 16kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human UBE2V1
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
泛素結(jié)合酶E2變異體1抗體說明書 產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Function : Has no ubiquitin ligase activity on its own. TheUBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonicalpoly-ubiquitin chains that are linked through Lys-63. This type ofpoly-ubiquitination activates IKK and does not seem to involveprotein degradation by the proteasome. Plays a role in theactivation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2.Mediates transcriptional activation of target genes. Plays a rolein the control of progress through the cell cycle anddifferentiation. Plays a role in the error-free DNA repair pathwayand contributes to the survival of cells after DNA damage.
Subunit : Heterodimer with UBE2N. Interacts (UBE2V2-UBE2Nheterodimer) with the E3 ligase STUB1 (via the U-box domain); thecomplex has a specific 'Lys-63'-linked polyubiquitination activity.Interacts with TRAF6.
Subcellular Location : Nucleus. Note=Excluded from the nucleolus.
Tissue Specificity : Highly expressed in thyroid, pancreas, spinalcord, lymph node, trachea, adrenal gland, bone marrow and pancreas.Detected at low levels in heart, breast, placenta, brain, liver,kidney, stomach and lung.
Similarity : Belongs to the ubiquitin-conjugating enzyme family.
Database links : UniProtKB/Swiss-Prot: Q13404.2
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